It is beaten into a paste with water and applied to chancres and ulcers on the penis. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. What are the Most Useful Ayurvedic Medicinal Plants? Oleander is extremely toxic and potentially fatal. Furthermore, subjects had pathological lesions that included hyperemia, hemorrhage, and coagulative necrosis without inflammatory cell infiltration or signs of pericarditis, myocarditis, or endocarditis.Khordadmehr 2018, A mixed-breed dog presented to emergency veterinary care services for vomiting and severe lethargy that quickly progressed to collapse. Inhibits NF-kB factor in cancer cells 4. It is most commonly known as oleander, from its superficial resemblance to the unrelated olive Olea, but has many other names. Extensive iron accumulation was found in the liver. Oleander has been used as an abortifacient.Bavunoglu 2016, Phytodermatitis caused by contact with oleander has been frequently reported. Serum oleandrin concentrations were 19.6 mcg/L and 7.5 mcg/L at 15.5 and 44 hours postingestion, respectively.Bataille 2018, A 44-year-old man who deliberately ingested flowers and leaves of 40 pink N. oleander plants developed vomiting, blurred vision, and diarrhea within 1 hour. Dermatitis may result when crushed leaves of the shrub come into contact with the skin of an individual with sensitivity to a prior exposure. This plant has potential toxic effect after ingestion. Treatment for this medical emergency includes the administration of activated charcoal and intravenous fluids. Medicinal uses of nerium oleander include treating ulcers, hemorrhoids, and leprosy. 1). The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Myeloperoxidase (MPO) activity increased in the NAE-8 treatment group, indicating inflammation was abolished. What are Different Types of Medicinal Plants. Scientific Name(s): Nerium oleander L.Common Name(s): Adelfa, Gandeera, Kaner, Karabi, Laurier rose, Oleander, Rosa francesa, Rosa laurel, Rose bay. I'd like to point out that botulism is an extremely deadly neurotoxin in extremely small doses, but people have Botox injections regularly. Almost all plant parts especially the leaves are frequently used for medicinal purposes . Due to its considerable toxicity, use of oleander or its constituents, such as oleandrin, is regarded as unsafe and potentially lethal. It grows to between 2 and 5 m in height and has long, narrow leaves almost 13 to 30 cm in length and typically grouped in threes around the stem. Oleander extract dates back to 15th Century B.C. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. I have researched a bit and found that harmful topical applications are from raw materials, are rare and generally an allergic reaction. From which you can learn a lot of new and interesting things, for example, that: Nerium Nerium oleander is a shrub or small tree in the dogbane family Apocynaceae, toxic in all its parts. Topical treatment with NAE-8 twice daily (2 mL/kg/day) for 14 days showed promising results in wound treatment. ECG readings began to normalize, symptoms resolved, and potassium returned to normal. Very terse details of medicinal uses of plants with a wide range of references and details of research … The patient was also given four 25 g doses of activated charcoal.Wong 2018, In a retrospective review of calls to one poison control center over 7 years related to human exposure to plants, one of the most common reasons for calls was oleander poisoning.Enfield 2018, A dog presented to a clinic 24 hours postingestion of an unknown amount of oleander leaves with detectable levels of digoxin (0.7 ng/mL); with no history of cardiac glycoside administration, the measured level was determined to be a result of oleander ingestion, confirming a diagnosis of oleander toxicosis. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. N. oleander also resulted in decreased serum MDA levels, which signifies lowering of lipid peroxidation.Dey 2015. The reduced TG-HDL ratio indicates that N. oleander treatment may prevent extensive coronary artery disease by decreasing atherogenic particles.Bas 2012, An extract of N. oleander administered to rats via intragastric route resulted in dose-dependent reductions in total cholesterol, TG, LDL, and very lowâdensity lipoprotein levels. Up-regulation of the BAAT gene with N. oleander supplementation decreased blood cholesterol levels and increased bile acid synthesis.Demirel Kars 2014, NOLE administered to mice orally for 20 days resulted in substantial decreases in liver marker enzymes, as well as in cholesterol and TG levels. Upon presentation, he was weakly ambulatory, displayed depressed mentation, ataxia, bradyarrhythmia, second-degree heart block, painful abdominal palpation, nausea, vomiting, and subcutaneous emphysema. Intoxication can occur from ingestion, or from inhalation of smoke from burned plants. Nerium oleander (N.O) (Apocynaceae) is an ornamental shrub distributed originally in the Mediterranean region, subtropical Asia, and the Indo-Pakistan subcontinent but is now growing in many parts of the world such as Australia, USA, China, and Middle East countries . Although people have used this supplement for centuries to treat a variety of ailments, nerium oleander is very toxic and should not be ingested. Symptoms included depression, restlessness, lacrimation, incoordination, pawing of the ground, convulsions, head circling, and anorexia. Wounds treated with N. oleander formulations showed an increase in tensile strength; the increase is indicative of improved collagenation, which significantly contributes to better and effective wound healing.Rout 2014, An aloe vera gelâbased extract of N. oleander (NAE-8) showed strong antioxidant capacity and provided better cellular antioxidant protection compared to treatment with an aqueous extract of N. oleander or an extract of aloe vera gel alone. An oil prepared from the root bark is used in the treatment of leprosy and skin diseases of a scaly nature. She was treated with 160 mg of digoxin immune Fab, followed 4 hours later with a second dose in addition to 50 g of activated charcoal. Medically reviewed by Drugs.com. Causes apoptosis in cancerous cells (natural cell death) 5. Digoxin immune Fab (ovine) injection (DigiFab) was administered 22 hours postingestion, with improvement observed 3 hours after treatment.Pao-Franco 2017, Mice and rats administered aqueous leaf and flower extracts of N. oleander via oral gavage at doses of 10 mg/kg, 12.5 mg/kg, 15 mg/kg, and 20 mg/kg displayed signs of toxicity, including anorexia, nervousness, depression, restlessness, crying, ataxia, pawing of the ground, convulsions, falling, and turning of the head backwards. To obtain medicinal food supplement from N. oleanderleaves a new oleander extraction method Distillation was used in this study finally the effects of distillate on MCF-7 cells were determined. Nerium Oleander has a 2000-year healing history and was used successfully for more than 30 years by Dr Ozel of Turkey as a treatment for cancer. Oleander Uses, Benefits & Dosage - Drugs.com Herbal Database Oleander administration may be beneficial in reducing microvascular and macrovascular risk of type 2 diabetes mellitus.Bas 2012, Rats with type 2 diabetes given N. oleander distillate at a dose of 375 mcg per 0.5 mL of distilled water by gavage once daily prevented type 2 diabetesâinduced altered lipid profile and cardiomyocytes dysfunction. Signs of toxicity include severe nausea, emesis, abdominal pain, cramping, diarrhea, hyperkalemia, hypertension, lethargy, hepatotoxicity, and nephrotoxicity. After NOLE treatment, additional promising results included normalization of HbA1c and insulin levels, increased glucose tolerance, and lowering of hepatic glycogen. Special attention must be given to cardiac function. Pulmonary metastasis subsequently developed and the patient began therapy with N. oleander extract (Anvirzel) at a dosage of 1.2 mL/m2/day IM for 2 months without the knowledge of her medical team. I am not a doctor. Indian and Chinese traditional medicinal systems have used the plant Nerium oleander and its extracts for hundreds of years in the treatment of a wide range of illness. In addition, the horse was experiencing cardiac arrhythmias. Currently oleander is being used as an herbal remedy to treat a variety of diseases including thyroid disease, cancer, diabetes, and HIV. Gastric lavage or induced emesis should be performed. Based on results, N. oleander was found to be both nephrotoxic and hepatotoxic.Khordadmehr 2017. This product may be unsafe when used before surgery or other medical procedures. Although consuming oleander and using it as a topical preparation is not recommended for anyone, it can be especially dangerous for pregnant women or those who are breast feeding. Sinus rhythm with right bundle branch block was noted by the end of the 30-minute infusion; she was discharged 72 hours later without further symptoms.TatlÄ±su 2015, A case of fatal hepatotoxicity probably associated with daily IM administration of N. oleander extract for 2 months was reported in a 43-year-old woman with a history of synovial sarcoma of the knee with pulmonary and bone metastasis, originally diagnosed 3 years prior. One study showed that N. oleander chloroform and petroleum ether leaf extracts inhibited Bacillus subtilis, Sarcina lutea, Escherichia coli, and Klebsiella pneumoniae, with the highest activity against E. coli.Jamal 2012 In another study, varying concentrations (10%, 25%, 50%, and 100%) of the ethanol extract of N. oleander showed a strong and broad spectrum of antimicrobial activity.Bidarigh 2012 The study demonstrated that N. oleander can be used for biocontrol of the early blight disease in yams, as indicated by antifungal activity against various plant pathogenic fungi and bacterial phytopathogens. Poisoning by these plants is a common toxicological emergency in tropical and subtropical parts of the world and intentional self-harm using T. peruviana is prevalent in South Asian countries, especially India and Sri Lanka. Treatment with NAE-8 also significantly reduced the increase in mean percentage of DNA in the tail triggered by burn injury, which may point to DNA repair capacity. Oleander vulgaris Medik. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. The plant, suitable to USDA Hardiness Zones 8 to 11, grows to between 6 and 20 feet in height. However, the lower affinity of digoxin-specific Fab for non-digoxin cardiac glycosides in oleander results in a larger dose requirement than for usual digoxin toxicity.Bandara 2010, Eddleston 2000, In a patient who ingested oleander, the serum digoxin levels were high (4.4 ng/mL) and were associated with bradyarrhythmias and tachyarrhythmias, which decreased as the serum concentration of the toxin decreased.Mesa 1991 Another patient who ingested 7 oleander leaves in a suicide attempt had digoxin serum levels of 5.69 nmol/L, according to a digoxin radioimmunoassay; this assay confirmed toxicity, but did not predict the severity of the toxicity.Romano 1990 A healthy 30-year-old man prepared and drank a syrup made from boiled N. oleander leaves for hemorrhoids; he was admitted to the hospital 8 hours later with complete atrioventricular block and bradycardic episodes that reverted to normal sinus rhythm 30 hours after treatment with charcoal, sodium sulfate, and electrolytes. Crude methanolic extracts and fractions of the N. oleander plant were studied against gram-negative and -positive bacteria, as well as fungus. During the 1960s, a Turkish doctor, Huseyin Ozel, saw that people using the remedy were mostly free of cancer and other serious diseases. NAE-8 protected cells from apoptosis and oxidation of intracellular glutathione following hydrogen peroxide exposure.Benson 2015 In another study, an oleandrin-free version of NAE-8 combined with a water-soluble egg membrane potentially supported reparative functions in skin based on increased cytokine production, activation of natural killer (NK) cells, increased chemokine production, and antiviral protection.Benson 2016, In another study, NAE-8 reduced elevated malondialdehyde (MDA) levels and reduced tumor necrosis factor (TNF)-alpha and IL-1beta levels in rats with second-degree burns covering 30% of total body surface area.
2020 nerium oleander medicinal uses